Trends in Tissue Engineering in 2018 * Opportunity & Innovations in the field of Regenerative Medicine

Tissue Engineering & Regenerative Medicine Patent Trends 2018

The field of regenerative medicine has exploded in the last decade. Regenerative medicine is a new way to cure patients besides traditional medicine and surgery. Regenerative medicine harnesses, in a clinically targeted manner, the ability of stem cells (i.e., the unspecialized master cells of the body) to renew themselves indefinitely and develop into mature specialized cells.

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What will be the Future Trends in Genomics?

The current clinical strategy primarily focuses on treating the symptoms of the disease. But with the rise in chronic diseases and organ failure, there is a large opportunity for regenerative medicines. Regenerative medicine is the future to treat current ailments. Stem cells have the ability to divide indefinitely, and to specialize into specific types of cells therefore, the regenerative medicine seeks to replace tissue or organs that have been damaged by disease, trauma, or congenital issues with the goal to cure previously untreatable injuries and diseases.


Stem cell therapy has been in development since the 1950s, and since then, new advancements and innovations in the field of regenerative medicines are coming up to provide solutions to some of the most challenging medical problems faced by humankind.  Regenerative medicines include pharmaceuticals, biopharmaceuticals, medical devices, cell therapies and some non-cell based treatments and have some of the most fascinating opportunities and hopes in regards to previously incurable diseases.

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Recent Patents filed in the field of “REGENERATIVE MEDICINE” domain

International Patent number WO/2017/221155 titled “AUTOMATED CELL PROCESSING SYSTEMS AND METHODS” was filed by GENESIS TECHNOLOGIES LIMITED having a patent publication date: 28 Dec 2017. The patent innovation provides systems and methods for automated cell processing of biological samples. The biological samples are the cells for use in cell therapy and regenerative medicine.

Systems for automated processing of batches derived from biological samples includes a closed and sterile enclosure; a plurality of reagent containers; at least one reagent dispenser; a quality control module for analyzing at least one characteristic of a batch; a harvesting module; a robotic module; and a control unit (CU) communicatively coupled to the at least one reagent dispenser, the quality control module, the harvesting module and the robotic module for controlling the automatic processing of batches. The automatic processing may be executable without handling by a human operator. The system may be configured to automatically process the plurality of batches without cross-contamination between batches, e.g., under GMP conditions.

International Patent number WO/2017/205541 titled “GROWTH-FACTOR NANOCAPSULES WITH TUNABLE RELEASE CAPABILITY FOR BONE REGENERATION” was filed by THE REGENTS OF THE UNIVERSITY OF CALIFORNIA having a patent publication date 30 Nov 2017.

The International Patent relates to growth factors are of great potential in regenerative medicine. However, their clinical applications are largely limited by short in vivo half-lives and a narrow therapeutic window. Thus, a robust controlled release system remains an unmet medical need for growth-factor-based therapies. A nanoscale controlled release system (degradable protein nanocapsule) is provided via in-situ polymerization on growth factor. The release rate can be finely tuned by engineering the surface polymer composition. Improved therapeutic outcomes are achieved with the growth factor nanocapsules, as illustrated in spinal cord fusion mediated by bone morphogenetic protein-2 (BMP-2) nanocapsules.

3. WO/2017/223373


Assignee: CITY OF HOPE

Publication Date: 28 Dec 2017


Disclosed herein are methods of treating Canavan disease in a subject through restoring ASPA enzymatic activities in the subject by expressing exogenous wild type ASPA gene in the brain of the subject. Also disclosed are a process of producing neural precursor cells, including NPCs, glial progenitor cells and oligodendroglial progenitor cells, which express an exogenous wild type ASPA gene and the neural precursor cells produced by this process.

Patent validity litigation will be more in Genomics.

4. WO/2017/218846



Publication Date: 21 Dec 2017


The present disclosure relates to cannabinoid compositions used in combination with stem cell therapies. These compositions can be encapsulated (e.g., microencapsulated). In particular, these compositions can be administered to a subject, such as through oral consumption or topical treatment.

5. US 20170296587



Publication Date: 19 Oct 2017


Disclosed are compositions of matter, protocols, and methods of treatment of neurological manifestations using stem cells, stem cell stimulators, and combination treatments. In one embodiment, a patient suffering neurological manifestations of a viral infection is administered a therapeutically active dose(s) of mesenchymal stem cells at a frequency and concentration sufficient to induce amelioration, remission or cure of neurological manifestations.

6. US 9763877

Title: Adult and neonatal stem cell therapy to treat diabetes through the repair of the gastrointestinal tract

Assignee: EndoCellutions, Inc.

Publication Date: 19 Sep 2017


The anatomic and functional arrangement of the gastrointestinal tract suggests an important function of this organ is its ability to regulate the trafficking of metabolites as well as control the equilibrium between tolerance and immunity through gut-associated lymphoid tissue, the neuroendocrine network, and the intestinal epithelial barrier. Combining nucleated cells from various tissues and introducing them directly into the small intestine will have a positive effect on diabetes.

7. WO/2017/189842



Publication Date: 2 Nov 2017


The invention provides methods for treating a patient suffering from a disease or condition or age-related symptom that is caused by stem cell dysfunction or increased senescence. The methods comprise administering to the patient a composition comprising extracellular vesicles obtained from stem cells or serum of a subject that is younger or healthier than, and of the same species as, the patient.

8. US 9821026

Title: Use of RET agonist molecules for haematopoietic stem cell expansion protocols and transplantation therapy and a RET agonist kit

Assignee: Instituto de Medicina Molecular

Publication Date: 21 Nov 2017


The present disclosure relates to the use of RET, a transmembrane tyrosine kinase receptor, agonist molecules for Haematopoietic Stem Cell (HSC) expansion protocols and HSC transplantation therapy.

RET signaling molecules are expressed by HSCs and Ret ablation leads to reduced HSC numbers. RET signals provide HSCs with critical Bcl2 and Bcl2l1 surviving cues, downstream of p38/MAP kinase and CREB activation. Accordingly, enforced expression of RET downstream targets, Bcl2 or Bcl2l1, is sufficient to restore the activity of Ret null progenitors in vivo. Remarkably, activation of RET improves HSC survival or maintenance and in vivo transplantation efficiency, thus opening new horizons to the usage of RET agonist in HSC expansion and transplantation protocols.

Additionally, the present disclosure describes a kit comprising RET agonist molecules, to be used in HSC expansion protocols and transplantation therapy.

Prity Khastgir and her team of thinking geeks provides patent research Litigation Research services for global clients for over a decade. Intellectual property strategy for regenerative medicine for research worldwide research organisations. Our patent attorneys and patent agents in India specialize in biotech disciplines, including proteomics, tissue engineering & environmental biology. The research attorneys, patent agents, and thinking geeks include experienced client advocates representing a scope of disciplines from across the biotech sector in India.

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International Patent Research Workshop for Intrigued Genius Minds

international patent WIPO, International Patent Research Workshop

Disrupting the Approach to Patent Research: Take your intelligence to next level. Welcome to the world of understanding innovations happening in cutting edge technologies across the globe. Learn more about current technology trends that will shape up economic disruptions across the globe. Learn more about innovations happening in the field of Artificial Intelligence, Cognitive Computing, understand use of chatbots, virtual agents, virtual assistants, wearables – augmented and virtual reality, IoT, Blockchain and other state of the art technology.

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Albert Einstein, Thomas Alva Edison and Wolfgang Amadeus Mozart all were genius people in their lifetime.

Now what set these people apart from the rest and made them achieve what they did? 

It’s pretty simple really: they all simplified the existence of existing laws and the way of seeing life in different way.

Every human is eligible to attain that height of being genius. CHOICE is YOUR whether to BELIEVE in YOUR IDEAS and #makeithappen

Imperfection is beauty, madness is genius and it’s better to be absolutely ridiculous than absolutely boring. – Marilyn Monroe

International Patent Research Workshop 

Venue: Aerocity, New Delhi

Demystifying Patent Research Basics

The patent research workshop will cover holistic view of the legal viewpoint

As to how to perform patentability search?

How to perform state of the art searches?

How to perform validity patent searches?

How to perform Infringement searches and freedom to operate searches?

As a company it is important to understand the type of research which needs to be performed to identify the OPPORTUNITIES to create your own niche in the competitive market. For example, patentability search can be performed if any person or any innovator of a company has an idea or is doing a research.

WHEN to perform patentability search before filing a patent or after filing provisional patent application?

The company would like to know What is the SWOT analysis or in simple terms, identifying what are the different innovations or research which has already happened across the globe.

As a business owner knowing what happens in 2-3 years from now is a strategic move

When to protect intellectual property?

It’s very tough question to answer and it is not very easy to protect every creation of mind. Yes, there are some ways in which you can actually add some pointers and then file a patent application. Ideas are creation of mind and it might happen at one point of time the same idea is bouncing in multiple minds at neutron level across the globe.

First very important factor for an innovation to be PATENT WORTHY is that an idea should be new. New means that idea should be new concept all over the world not only in India. So the idea actually qualify for even being patent worthy is performing patentability research. Many patent databases are very helpful to perform the patentability. One example is WIPO which stands for world intellectual property organisation.

The WIPO database is worldwide patent database. Other important databases are espacenet, and USPTO.

Many times we get patent queries regarding what kind of patent databases are you using for performing your any kind of patentability or any kind of patent research?

Our BELIEVE is SIMPLE we use our intellect and use non paid patent tools.

Obviously, when you are using a paid database it is expensive. However, you are not using your intellect as a patent attorney or as a patent researcher to come up with ways and means to do your research in a manner which suffice the purpose of that particular invention or idea so that is very very important.

Over the years we have been able to find out better results by defining the kind of scope of work which we plan when we get a patent research query.

There is no STEP WISE MANTRA that would be applicable in all the patent searches. What is important is to analyse CRUX of the invention or the innovative features of the invention use your intellect as a patent researcher, and make the key strings.

What kind of patent strings will work better and if you have less time how to go about doing state of the art searches?

State of art search is basically talks about what kind of innovation already has happened in a particular sector. For example it can be a solar sector where by solar energy is being used to light up the lamp or it can be a LED sector where the technology relates to packaging of the LED to reduce the heat sink capacity. However, what is important to understand what kind of approach or parameters are you going to take into considerations as a patent researcher.

patent research, Artificial Intelligence, Cognitive Computing, understand use of chatbots, virtual agents, virtual assistants, wearables - augmented and virtual reality, IoT, Blockchain

KEY Learnings from International Patent Research Workshop

We will be discussing a lot on different kind of technologies. It is exciting to know that YOU don’t have to be an expert in a particular technology to do a patent research. Obviously, if you are a scientist or Phd in particular area it will take less time to understand the technology but at the same time as a patent researcher or as a patent attorney one should understand your job is to identify the innovative features.

Imbibing the acumen of a researcher and techno legal domain will is helpful when you are responding to office section response. The office action response is issued by the patent examiner and the patent examiner performs the search on a particular invention and will come up with objections so as a patent expert or patent attorney you need to respond to those objections. How to respond to office action response will be part of different workshop which we would be doing in the coming months.

How different kind of patent strategies can be applied as there is no one strategy which will be applicable to all patent searches but of course that key take away from the workshop would be that you would be able to understand what are the parameters you should actually look when you are doing the research.

Multinationals are coming in India so there is lot of job opportunities which are going to be there in near future and if you are already in the league of understanding how to perform patent research and can STRATEGISE a BUSINESS PLAN for the startup you get yourself a high package job.

You will be in a position to help the companies with their day to day activities whereby a lot of research is being performed by the scientists and many a times they have no clue whatsoever

What kind of patent research is of prime importance? 

What kind of patent research should be finished first? 

What kind of research is being done by competitors? 

For any questions we are reachable at